From Montréal

• Highway 20 East up to Québec City
• In Québec City, take Highway 73 North to Highway 440 East
• Highway 440 East to Route 138 East
• Route 138 East up to Sept-Îles (Route 138 becomes Laure Blvd in Sept-Îles)
  
  

From Québec City

• Highway 73 North to Highway 440 East
• Highway 440 East to Route 138 East
• Route 138 East up to Sept-Îles (Route 138 becomes Laure Blvd in Sept-Îles)
  

From Chicoutimi

• Highway 172 to Route 138 East
• Route 138 East up to Sept-Îles (Route 138 becomes Laure Blvd in Sept-Îles)
  

From Ottawa

• Trans Canada 417 East (Ontario) to Highway 40 East (Québec)
• Highway 40 East to Highway 25 South
• Highway 25 South to Highway 20 East
• Highway 20 East up to Québec City
• From Québec City, Highway 73 North to Highway 440 East
• Highway 440 East to Route 138 East
• Route 138 East up to Sept-Îles (Route 138 becomes Laure Blvd in Sept-Îles)
  
  

From Toronto

• Route 404 North to Highway 401 East
• Highway 401 East (Ontario) becomes Highway 20 East (Québec)
• Highway 20 East to Highway 13 North
• Highway 13 North to Highway 40 East
• Highway 40 East to Highway 25 South
• Highway 25 South to Highway 20 East
• Highway 20 East up to Québec City
• From Québec City, Highway 73 North to Highway 440 East
• Highway 440 East to Route 138 East
• Route 138 East up to Sept-Îles (Route 138 becomes Laure Blvd in Sept-Îles)